March 23, 2018

Understanding Rosacea: Immune Response and Inflammation

Our immune systems are our body’s first line of defence against infection-causing bacteria, viruses or other pathogens. The activation of the immune system results in an inflammatory response as the body protects and fends for itself.

A properly-functioning immune system is activated by the presence of harmful or unwanted substances, and the inflammatory response ceases when the threat has stopped. But in people with rosacea, the immune system appears to over-react and produce higher levels of substances that cause inflammation.

Dermatologist Dr Del Rosso named inflammation and neurovascular dysregulation (abnormality in the regulatory functions of nerves and blood vessels) as two main characteristics of rosacea-prone skin. In their scientific paper on rosacea, Del Rosso and colleagues wrote, “Current evidence supports neurovascular dysregulation and altered immune response as integral components of vasodilatory reactivity and ‘neurogenic’ symptoms such as stinging and burning.”

Besides avoiding triggers and adhering to prescribed medications, a suitable skin care regimen will go a long way in managing rosacea.

ZO Medical has recently launched Rozatrol™, a daily treatment serum which simultaneously works to control key symptoms of rosacea including inflammation, vascular degeneration (the appearance of blood vessels on the skin), decreased cellular renewal, excess oil and neuro-aging.

Rozatrol™ is part of the ZO® Skin Normalizing System— a complete selection of products recommended by Dr Zein Obagi to treat red, sensitized skin. Ask your dermatologist or healthcare provider if this is suitable for you.

Step Product Purpose Frequency
1 Fomacleanse Cleanse Daily; AM & PM
2 Offects Exfoliating Polish Exfoliate Daily; AM
3 Cebatrol™ Oil Control Pads Treat Daily; AM & PM
4 Ossential Daily Power Defense Protect and optimize skin pH Daily; AM & PM
5 Rozatrol™ Normalizing Serum Treat Daily; AM & PM
6 Oclipse® Sunscreen + Primer Broad-spectrum SPF 30 UVA/UVB Protection Sun Protection Daily; reapply every 2 hours in the day time


Del Rosso JQ, Gallo RL, Kircik L, et al. Why is rosacea considered to be an inflammatory disorder? The primary role, clinical relevance, and therapeutic correlations of abnormal innate immune response in rosacea-prone skin. J Drugs Dermatol. 2012;11:694-700.

Tags: rosacea, skincare, immune response, inflammation, Rozatrol